Background: A healthy diet provides the body with essential nutrition that includes fluids, macronutrients, micronutrients, and calories. The liver is one of the most important organs in the body that has the function of detoxification and cleansing, and smoking causes an additional burden for the detoxification function of the liver, which can lead to inflammation and fatty liver. This study was designed to investigate the effects of smoking on liver function. Materials and Methods: This cross-sectional descriptive-analytical study investigated the relationship between smoking and the type of nutrition of liver enzymes in healthy people and people who smoke in Zabol. In this study, 150 people were selected who were divided into two groups of healthy people without smoking (n = 75) and people with smoking with liver problems (n = 75). Results: There was no statistical relationship between age and levels of aspartate AMINOTRANSFERASE (AST) and ALANINE AMINOTRANSFERASE (ALT) liver enzymes (P > 0. 05). However, a relationship was found between weight and levels of liver enzymes AST and ALT. Hepatitis also increased (P < 0. 05), and there was a statistical relationship between alcohol consumption with AST and ALT liver enzymes,more precisely, the more alcohol consumption, the higher the amount of liver enzymes (P < 0. 05). Finally, no statistically significant relationship was observed between fruit and vegetable consumption, rice consumption, meat consumption, and water consumption (P > 0. 05). Conclusion: This relationship is positive and direct,in other words, the higher the consumption of tobacco, the higher the activity of liver enzymes ALT and AST.